ZNF415

Across TCGA cell cohorts, ZNF415 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF415-associated genes across cancer lineages are PRAMEF6, CRYGD, and GNG8. Each is linked with ZNF415 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF415-to-partner and partner-to-ZNF415 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF6 grouped by ZNF415-low versus ZNF415-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF415→partner) and Y-score (partner→ZNF415) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRAMEF6 →	+0.166	+5.754	<.001	.002	3	2
LUNG_NSCLC_LUAD	CRYGD →	+0.030	+4.887	.003	.009	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.268	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	C10orf71 →	+0.029	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4A47 →	+0.018	+5.228	<.001	.005	3	1
SKIN	OR2K2 →	+0.042	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PRAMEF6 by ZNF415 expression — CNS

Explore this box plot interactively →