ZNF415

Across TCGA pan-cancer cohorts, ZNF415 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZNF415 data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF415 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF415 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, KICH, and HNSC are the cancer types where ZNF415 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.778	0.455	<.001	94	view →
KICH	DFS	Tertile	II,III,IV	0.492	1.000	.001	82	view →
HNSC	DFS	Tertile	III,IV	0.705	0.494	<.001	61	view →
LUSC	DFS	Tertile	All	0.556	0.754	<.001	58	view →
SCLC	OS	Tertile	III,IV	0.266	0.690	.001	44	view →
ACC	OS	Tertile	IV	0.777	0.253	.001	43	view →
KIRC	OS	Tertile	All	0.864	0.754	.002	38	view →
READ	DFS	Quartile	IV	0.340	0.852	.011	34	view →
LGG	OS	Tertile	All	0.736	0.870	<.001	33	view →
DLBC	OS	Quartile	II,III,IV	0.589	1.000	.014	12	view →
ESCA	DFS	Tertile	III,IV	0.560	0.268	.008	12	view →
COAD	OS	Quartile	IV	0.733	0.254	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZNF415–UVM (OS)

Open the UVM breakdown →