ZNF404

Across TCGA patient cohorts, ZNF404 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,209 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ZNF404-associated proteins across cancer lineages are USP15_S229, CLPX, and EPM2AIP1. Each is linked with ZNF404 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF404-to-partner and partner-to-ZNF404 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF404 versus USP15_S229 in HNSC, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF404→partner) and Y-score (partner→ZNF404) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	USP15_S229 →	-0.490	-0.454	<.001	.009	3	4
PDAC	CLPX →	-0.236	-0.436	.002	<.001	3	4
BRCA	EPM2AIP1 →	+0.381	+0.613	<.001	.001	3	4
GBM	LMNB2 →	+0.296	+0.924	<.001	<.001	3	4
GBM	TRIM28 →	+0.278	+0.748	<.001	<.001	3	4
PDAC	NUDC_S139 →	-0.450	-0.515	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,209 associations by consensus.

ZNF404 vs USP15_S229 — HNSC

Explore this scatter interactively →