ZNF404

Across TCGA pan-cancer cohorts, ZNF404 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF404 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZNF404 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF404 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BLCA show a favorable association.

KIRC, PAAD, and BLCA are the cancer types where ZNF404 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.481	0.726	.001	124	view →
PAAD	OS	Median	All	0.689	0.338	<.001	45	view →
BLCA	OS	Quartile	All	0.653	0.528	.014	42	view →
READ	DFS	Tertile	All	0.710	0.920	.005	30	view →
STAD	DFS	Median	All	0.480	0.633	.008	27	view →
ACC	OS	Quartile	IV	0.858	0.362	.006	18	view →
UVM	DFS	Tertile	All	0.282	0.896	.019	17	view →
LUAD	OS	Tertile	II,III,IV	0.755	0.643	.018	16	view →
LUSC	DFS	Tertile	III,IV	0.544	0.762	.006	13	view →
HNSC	DFS	Quartile	All	0.542	0.786	.004	13	view →
UCEC	OS	Tertile	IV	0.708	0.264	.026	12	view →
LIHC	OS	Quartile	All	0.667	0.846	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF404–KIRC (OS)

Open the KIRC breakdown →