ZNF404

Across TCGA pan-cancer cohorts, ZNF404 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF404’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF404 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF404 is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

COAD, UCEC, and KIRC are the cancer types where ZNF404 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF404 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.432	<.001	9	view →
UCEC	All	III,IV	−1.526	<.001	6	view →
KIRC	Female	All	−0.445	.004	5	view →
CHOL	Male	All	+1.589	<.001	4	view →
LIHC	All	All	+0.413	<.001	4	view →
BRCA	Female	All	−0.412	<.001	4	view →
READ	All	III,IV	−1.054	.004	3	view →
KIRP	All	All	−0.463	.014	2	view →
STAD	All	II,III,IV	−0.377	.035	2	view →
HNSC	All	II,III,IV	−0.194	.032	2	view →
BLCA	All	IV	−0.660	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF404–COAD

Open the COAD breakdown →