ZNF404

Across TCGA patient cohorts, ZNF404 mutation is significantly associated with the RNA expression of many other genes, with 2,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF404-associated genes across cancer lineages are SKP1P3, RNA5SP399, and SNORD116-6. Each is linked with ZNF404 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF404-to-partner and partner-to-ZNF404 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKP1P3 grouped by ZNF404-low versus ZNF404-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF404→partner) and Y-score (partner→ZNF404) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SKP1P3 →	+0.050	+4.221	<.001	.008	3	3
HNSC	RNA5SP399 →	+0.254	+4.015	<.001	.003	3	2
HNSC	SNORD116-6 →	+0.383	+3.867	.001	.002	3	2
COAD	ANKRD30BP1 →	+0.322	+3.159	.002	.006	3	2
UCEC	RNA5SP412 →	+0.624	+2.201	<.001	<.001	3	2
UCEC	CC2D1B →	+0.270	+2.148	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,659 associations by consensus.

SKP1P3 by ZNF404 expression — HNSC

Explore this box plot interactively →