ZNF404

Across TCGA patient cohorts, ZNF404 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF404-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and EGFR. Each is linked with ZNF404 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF404-to-partner and partner-to-ZNF404 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF404-low versus ZNF404-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF404→partner) and Y-score (partner→ZNF404) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.258	-3.087	.004	<.001	3	3
UCEC	Shc_pY317 →	-0.111	-1.584	.043	.019	3	2
UCEC	EGFR →	-0.128	-2.000	.026	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.155	-2.584	.010	.010	3	1
UCEC	MSH2 →	-0.242	-2.089	.003	.016	3	1
UCEC	NF-kB-p65_pS536 →	-0.337	-1.990	.039	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by ZNF404 expression — UCEC

Explore this box plot interactively →