ZNF404

Across TCGA cell cohorts, ZNF404 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,719 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZNF404-associated GO terms across cancer lineages are Regulation of macroautophagy, Protein localization to vacuole, and Transcytosis. Each is linked with ZNF404 in more than 9 cancer types. Because this analysis shows association rather than direction, both ZNF404-to-partner and partner-to-ZNF404 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by ZNF404-low versus ZNF404-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF404→partner) and Y-score (partner→ZNF404) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of macroautophagy →	+0.041	+0.954	.003	.002	2	10
URINARY_TRACT	Protein localization to vacuole →	+0.064	+1.033	.009	.008	2	9
KIDNEY	Transcytosis →	+0.124	+0.948	.001	.002	3	8
BONE	Golgi vesicle transport →	+0.063	+1.844	.003	<.001	3	8
CNS	Protein targeting →	+0.044	+1.074	<.001	<.001	3	8
PANCREAS	Vesicle coating →	+0.082	+1.090	<.001	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,719 associations by consensus.

Regulation of macroautophagy by ZNF404 expression — OVARY

Explore this box plot interactively →