ZNF345

Across TCGA patient cohorts, ZNF345 mutation is significantly associated with the RNA expression of many other genes, with 5,471 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF345-associated genes across cancer lineages are UBE2F, RPL23AP82, and CDCA2. Each is linked with ZNF345 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF345-to-partner and partner-to-ZNF345 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2F grouped by ZNF345-low versus ZNF345-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF345→partner) and Y-score (partner→ZNF345) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2F →	+0.287	+1.399	<.001	.005	3	3
UCEC	RPL23AP82 →	+0.472	+2.061	<.001	<.001	3	3
UCEC	CDCA2 →	+0.892	+2.050	<.001	<.001	3	3
UCEC	XRCC6 →	+0.542	+2.928	<.001	<.001	3	3
COAD	FAM118B →	+0.563	+3.391	<.001	.004	3	3
UCEC	KIFBP →	+0.396	+1.839	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,471 associations by consensus.

UBE2F by ZNF345 expression — UCEC

Explore this box plot interactively →