ZNF345

Across TCGA patient cohorts, ZNF345 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF345-associated genes across cancer lineages are FASN, ASNS, and eEF2. Each is linked with ZNF345 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF345-to-partner and partner-to-ZNF345 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ZNF345-low versus ZNF345-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF345→partner) and Y-score (partner→ZNF345) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.308	+1.584	.010	.017	3	4
COAD	ASNS →	+0.530	+2.593	.001	.006	3	3
UCEC	eEF2 →	+0.312	+2.807	.004	.002	3	2
UCEC	EGFR_pY1068 →	-0.249	-1.999	.001	.008	3	2
COAD	ERK2 →	+0.212	+1.900	.008	.030	3	2
UCEC	FoxM1 →	+0.165	+1.473	.037	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

FASN by ZNF345 expression — UCEC

Explore this box plot interactively →