ZNF280C

Across TCGA patient cohorts, ZNF280C mutation is significantly associated with the RNA expression of many other genes, with 3,988 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280C-associated genes across cancer lineages are TUBB4BP7, H3P42, and MIR3193. Each is linked with ZNF280C in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280C-to-partner and partner-to-ZNF280C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB4BP7 grouped by ZNF280C-low versus ZNF280C-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280C→partner) and Y-score (partner→ZNF280C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TUBB4BP7 →	+0.081	+3.776	<.001	.002	3	2
READ	H3P42 →	+0.132	+3.469	<.001	.007	3	2
UCEC	MIR3193 →	+0.292	+1.405	.004	.009	3	2
CESC	MIR4674 →	+0.782	+5.103	<.001	.008	3	2
COAD	RN7SKP214 →	+0.682	+3.412	<.001	.006	3	2
COAD	RNU6-693P →	+0.302	+4.721	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,988 associations by consensus.

TUBB4BP7 by ZNF280C expression — READ

Explore this box plot interactively →