ZNF280C

Across TCGA pan-cancer cohorts, ZNF280C RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZNF280C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF280C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF280C is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where ZNF280C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF280C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.048	<.001	12	view →
COAD	Male	All	+1.072	<.001	11	view →
KIRP	All	IV	+1.002	<.001	11	view →
BLCA	All	All	+0.726	<.001	10	view →
LIHC	Male	All	+0.736	<.001	9	view →
STAD	All	II,III,IV	+0.895	<.001	8	view →
LUAD	Male	All	+0.592	<.001	8	view →
LUSC	Male	All	+0.878	<.001	7	view →
UCEC	All	II,III,IV	+1.170	.009	6	view →
CHOL	All	All	+1.369	<.001	5	view →
READ	All	All	+1.116	<.001	5	view →
THCA	All	All	−0.315	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZNF280C–HNSC

Open the HNSC breakdown →