ZNF280B

Across TCGA patient cohorts, ZNF280B mutation is significantly associated with the RNA expression of many other genes, with 2,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF280B-associated genes across cancer lineages are LINC00400, RPL12P48, and RNU6-1309P. Each is linked with ZNF280B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF280B-to-partner and partner-to-ZNF280B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00400 grouped by ZNF280B-low versus ZNF280B-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF280B→partner) and Y-score (partner→ZNF280B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC00400 →	+0.074	+4.182	<.001	.002	3	2
COAD	RPL12P48 →	+0.470	+3.437	<.001	.006	3	2
CESC	RNU6-1309P →	+0.445	+3.934	.005	.005	3	2
CESC	RPL23AP76 →	+0.095	+3.653	.004	.009	3	2
LUSC	MIR6846 →	+0.348	+4.257	<.001	.007	3	2
CESC	DYNLL1P5 →	+0.108	+4.384	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,555 associations by consensus.

LINC00400 by ZNF280B expression — HNSC

Explore this box plot interactively →