ZNF280B

Across TCGA pan-cancer cohorts, ZNF280B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF280B data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ZNF280B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF280B expression acts as an unfavorable survival marker, although some lineages such as READ and BLCA show a favorable association.

READ, BLCA, and SCLC are the cancer types where ZNF280B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.718	0.390	<.001	94	view →
BLCA	OS	Tertile	IV	0.721	0.491	.003	49	view →
SCLC	DFS	Median	II,III,IV	0.738	0.362	<.001	35	view →
HNSC	DFS	Tertile	III,IV	0.551	0.250	.004	33	view →
ACC	DFS	Median	All	0.230	0.682	<.001	26	view →
BRCA	OS	Tertile	IV	0.989	0.471	.006	21	view →
OV	DFS	Quartile	III,IV	0.411	0.323	.024	18	view →
PCPG	OS	Tertile	All	1.000	0.875	.011	18	view →
LGG	OS	Tertile	All	0.844	0.684	.005	12	view →
UCS	OS	Tertile	IV	0.756	0.323	.024	12	view →
LUSC	DFS	Median	All	0.479	0.307	.003	11	view →
LIHC	DFS	Median	III,IV	0.568	0.242	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF280B–READ (DFS)

Open the READ breakdown →