ZNF274

Across TCGA patient cohorts, ZNF274 mutation is significantly associated with the RNA expression of many other genes, with 1,021 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF274-associated genes across cancer lineages are MBD3L2, SFPQP1, and MIR6882. Each is linked with ZNF274 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF274-to-partner and partner-to-ZNF274 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L2 grouped by ZNF274-low versus ZNF274-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF274→partner) and Y-score (partner→ZNF274) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MBD3L2 →	+0.231	+4.563	<.001	<.001	3	3
LUAD	SFPQP1 →	+0.038	+3.938	<.001	.003	3	3
BRCA	MIR6882 →	+0.383	+4.506	<.001	.009	3	2
SKCM	RPL26P29 →	+0.191	+2.927	<.001	<.001	3	2
BRCA	HLTF-AS1 →	+0.115	+4.800	<.001	.006	3	2
UCEC	ERO1B →	+0.756	+2.447	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,021 associations by consensus.

MBD3L2 by ZNF274 expression — LUSC

Explore this box plot interactively →