ZNF227

Across TCGA cell cohorts, ZNF227 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF227-associated genes across cancer lineages are CST8, MAS1, and LHCGR. Each is linked with ZNF227 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF227-to-partner and partner-to-ZNF227 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST8 grouped by ZNF227-low versus ZNF227-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF227→partner) and Y-score (partner→ZNF227) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MAS1 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	LHCGR →	+0.063	+4.467	<.001	.004	3	1
LARGE_INTESTINE	FIGLA →	+0.037	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DEFB132 →	+0.074	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FAM205C →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CST8 by ZNF227 expression — LARGE_INTESTINE

Explore this box plot interactively →