Q-omics provides the consensus-scored FAM205C profile across patient tissues and cancer cell-line models. FAM205C expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, FAM205C is differentially expressed in 13, with the highest sampling consensus in KICH. Additionally, FAM205C RNA expression shows 9,107 significant gene co-expression associations, with the highest sampling consensus in STAD. Together, these results highlight UVM, KICH, and STAD as cancer lineages where FAM205C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM205C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM205C survival associations across molecular data types. FAM205C RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM205C RNA expression–survival associations across cancer types. High FAM205C expression shows unfavorable associations in THCA, READ, KIRP and LUAD, but favorable associations in UVM and ESCA. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .004). Together, the overview and detailed table identify UVM as the clearest survival context for FAM205C RNA expression.
This table summarizes FAM205C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for FAM205C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM205C shows lower tumor expression in KICH, KIRP, BRCA, UCEC and THCA and higher tumor expression in KIRC. The KICH box plot shows higher FAM205C RNA expression in normal versus tumor tissue (log2 FC = −0.225, t-test p < 0.001).
This table shows molecular features associated with FAM205C in patient tissues and cancer cell lines. In patient samples, FAM205C shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM205C RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE.
