ZNF224

Across TCGA cell cohorts, ZNF224 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF224-associated genes across cancer lineages are WFDC11, GJA8, and MAS1. Each is linked with ZNF224 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF224-to-partner and partner-to-ZNF224 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC11 grouped by ZNF224-low versus ZNF224-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF224→partner) and Y-score (partner→ZNF224) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	WFDC11 →	+0.096	+4.392	<.001	.004	3	1
STOMACH	GJA8 →	+0.020	+5.285	<.001	.003	3	1
STOMACH	MAS1 →	+0.006	+5.285	<.001	.003	3	1
STOMACH	BMP15 →	+0.043	+5.285	<.001	.003	3	1
STOMACH	LCE6A →	+0.046	+5.285	<.001	.003	3	1
CNS	OR2M5 →	+0.035	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

WFDC11 by ZNF224 expression — SOFT_TISSUE

Explore this box plot interactively →