ZNF224

Across TCGA pan-cancer cohorts, ZNF224 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF224 data layer compared with 6 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ZNF224 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF224 expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

BLCA, LGG, and HNSC are the cancer types where ZNF224 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.685	0.545	<.001	117	view →
LGG	DFS	Median	All	0.629	0.843	<.001	53	view →
HNSC	DFS	Tertile	All	0.782	0.645	.003	51	view →
ACC	DFS	Tertile	All	0.463	0.822	.001	37	view →
UVM	DFS	Quartile	III,IV	0.183	0.823	<.001	29	view →
SKCM	OS	Tertile	All	0.400	0.277	.008	26	view →
BRCA	OS	Median	All	0.976	0.947	.002	24	view →
PAAD	DFS	Median	All	0.421	0.299	.017	23	view →
READ	OS	Median	II,III,IV	0.740	0.464	.004	23	view →
KIRC	DFS	Tertile	II,III,IV	0.391	0.620	.003	20	view →
LAML	DFS	Median	All	0.519	0.284	.022	14	view →
THYM	DFS	Median	III,IV	1.000	0.480	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF224–BLCA (DFS)

Open the BLCA breakdown →