ZNF208

Across TCGA patient cohorts, ZNF208 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF208-associated genes across cancer lineages are 4E-BP1, 4E-BP1_pT37_T46, and eIF4E. Each is linked with ZNF208 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF208-to-partner and partner-to-ZNF208 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZNF208-low versus ZNF208-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF208→partner) and Y-score (partner→ZNF208) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.313	+1.807	.004	.025	3	4
LUAD	4E-BP1_pT37_T46 →	+0.287	+1.891	.022	.027	3	3
STAD	eIF4E →	+0.210	+2.321	.001	.005	3	3
STAD	ER-alpha →	-0.198	-2.300	.001	.005	3	3
STAD	c-Kit →	-0.323	-1.807	.006	.025	3	3
UCEC	EGFR_pY1068 →	-0.207	-1.415	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

4E-BP1 by ZNF208 expression — STAD

Explore this box plot interactively →