ZNF208

Across TCGA pan-cancer cohorts, ZNF208 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF208’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF208 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF208 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and KIRC are the cancer types where ZNF208 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF208 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−1.013	<.001	8	view →
LUSC	Female	All	−0.233	<.001	8	view →
KIRC	Male	All	−0.346	<.001	7	view →
UCEC	All	All	−1.063	<.001	6	view →
BRCA	All	All	−0.454	<.001	6	view →
COAD	All	II,III,IV	−0.132	.001	6	view →
LIHC	All	All	+0.207	<.001	5	view →
KIRP	Male	All	−0.497	<.001	4	view →
STAD	All	All	−0.208	.014	3	view →
READ	All	All	−0.302	.010	2	view →
PRAD	All	All	−0.205	.001	2	view →
CHOL	Male	All	+0.081	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF208–KICH

Open the KICH breakdown →