ZNF208

Across TCGA cell cohorts, ZNF208 mutation is significantly associated with the RNA expression of many other genes, with 398 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF208-associated genes across cancer lineages are VARS2, HMX1, and CLEC11A. Each is linked with ZNF208 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF208-to-partner and partner-to-ZNF208 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VARS2 grouped by ZNF208-low versus ZNF208-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF208→partner) and Y-score (partner→ZNF208) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VARS2 →	+0.507	+3.087	.008	.006	3	3
PANCREAS	HMX1 →	+0.023	+3.491	.005	.008	3	2
LARGE_INTESTINE	CLEC11A →	+1.449	+3.234	<.001	.004	3	2
LARGE_INTESTINE	INTS14 →	+0.402	+3.321	.008	.003	3	2
LARGE_INTESTINE	C5orf38 →	+1.530	+3.304	.006	.005	3	2
LARGE_INTESTINE	HMX3 →	+0.472	+2.379	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

VARS2 by ZNF208 expression — SKIN

Explore this box plot interactively →