ZNF205

Across TCGA patient cohorts, ZNF205 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF205-associated genes across cancer lineages are eIF4E, TFRC, and c-Jun_pS73. Each is linked with ZNF205 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF205-to-partner and partner-to-ZNF205 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF205-low versus ZNF205-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF205→partner) and Y-score (partner→ZNF205) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.258	+3.598	.001	.001	3	2
UCEC	TFRC →	+0.546	+3.459	.006	.005	3	2
UCEC	c-Jun_pS73 →	-0.144	-2.308	.015	.033	3	2
UCEC	ACC_pS79 →	+0.306	+1.594	.018	.042	3	1
UCEC	ACC1 →	+0.382	+2.335	.005	.018	3	1
UCEC	Heregulin →	-0.143	-1.906	.002	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by ZNF205 expression — UCEC

Explore this box plot interactively →