ZNF205

Across TCGA pan-cancer cohorts, ZNF205 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF205 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF205 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF205 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, LIHC, and ACC are the cancer types where ZNF205 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.955	0.367	<.001	84	view →
LIHC	DFS	Tertile	All	0.426	0.625	<.001	62	view →
ACC	OS	Quartile	II,III,IV	0.562	0.903	.001	60	view →
HNSC	OS	Quartile	III,IV	0.838	0.717	.011	24	view →
PRAD	DFS	Tertile	All	0.699	0.927	<.001	22	view →
BLCA	OS	Tertile	IV	0.179	0.644	.007	21	view →
DLBC	DFS	Median	All	0.780	0.419	.011	20	view →
LUSC	DFS	Median	III,IV	0.512	0.914	.006	19	view →
BRCA	OS	Median	IV	0.712	0.193	.003	14	view →
CHOL	OS	Quartile	All	0.376	0.867	.019	12	view →
GBM	DFS	Tertile	All	0.417	0.169	.003	9	view →
SKCM	OS	Tertile	All	0.206	0.537	.004	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF205–UVM (OS)

Open the UVM breakdown →