ZNF205

Across TCGA cell cohorts, ZNF205 mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF205-associated genes across cancer lineages are HOXD3, RAP1GDS1, and LGI3. Each is linked with ZNF205 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF205-to-partner and partner-to-ZNF205 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXD3 grouped by ZNF205-low versus ZNF205-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF205→partner) and Y-score (partner→ZNF205) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HOXD3 →	+0.150	+4.345	.001	<.001	3	2
BLOOD_Leukemia	RAP1GDS1 →	+1.011	+3.115	<.001	.009	3	2
LARGE_INTESTINE	LGI3 →	+0.270	+3.392	.001	.003	3	2
LARGE_INTESTINE	MAPT →	+1.529	+3.212	<.001	.006	3	2
LARGE_INTESTINE	PRKCQ →	+0.740	+3.064	.006	.009	3	2
URINARY_TRACT	COX4I2 →	+0.090	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

HOXD3 by ZNF205 expression — BLOOD_Leukemia

Explore this box plot interactively →