ZNF180

Across TCGA patient cohorts, ZNF180 mutation is significantly associated with the RNA expression of many other genes, with 3,303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF180-associated genes across cancer lineages are GAS2L1, WDR5, and RN7SKP264. Each is linked with ZNF180 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF180-to-partner and partner-to-ZNF180 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAS2L1 grouped by ZNF180-low versus ZNF180-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF180→partner) and Y-score (partner→ZNF180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAS2L1 →	+0.387	+1.530	.002	.004	3	3
UCEC	WDR5 →	+0.488	+2.032	<.001	<.001	3	3
UCEC	RN7SKP264 →	+0.138	+1.596	<.001	.008	3	3
LUAD	RNU6-32P →	+0.623	+3.832	.007	.003	3	3
UCEC	GFI1 →	+0.441	+2.584	<.001	<.001	3	3
SKCM	ENTR1 →	+0.536	+3.331	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,303 associations by consensus.

GAS2L1 by ZNF180 expression — UCEC

Explore this box plot interactively →