ZNF180

Across TCGA pan-cancer cohorts, ZNF180 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF180’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF180 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF180 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where ZNF180 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF180 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.150	<.001	10	view →
BLCA	All	III,IV	+0.606	<.001	9	view →
LIHC	All	II,III,IV	+0.494	<.001	7	view →
CHOL	Male	All	+1.191	<.001	5	view →
STAD	All	All	+0.436	.004	4	view →
LUAD	All	IV	+1.120	.026	2	view →
KIRP	Male	All	−0.477	<.001	2	view →
ESCA	All	All	+0.339	.004	2	view →
LUAD	Female	II,III,IV	−0.310	.022	2	view →
PRAD	All	All	+0.184	.041	2	view →
KICH	All	All	−0.384	.021	1	view →
LUSC	All	All	+0.257	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

ZNF180–THCA

Open the THCA breakdown →