ZNF114

Across TCGA patient cohorts, ZNF114 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF114-associated genes across cancer lineages are ERK2, PDCD4, and Caspase-7-cleavedD198. Each is linked with ZNF114 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF114-to-partner and partner-to-ZNF114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZNF114-low versus ZNF114-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF114→partner) and Y-score (partner→ZNF114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.180	+3.169	.033	.018	3	2
UCEC	PDCD4 →	-0.426	-3.169	.038	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.770	+3.341	.002	.005	3	2
UCEC	MSH2 →	-0.275	-3.143	.006	.018	3	1
UCEC	STAT5a →	+0.400	+2.999	.022	.035	3	1
UCEC	ATM →	-0.556	-3.156	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by ZNF114 expression — UCEC

Explore this box plot interactively →