ZMYND8

Across TCGA patient cohorts, ZMYND8 mutation is significantly associated with the RNA expression of many other genes, with 3,481 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMYND8-associated genes across cancer lineages are GPHN, PSMB6, and ERO1A. Each is linked with ZMYND8 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZMYND8-to-partner and partner-to-ZMYND8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHN grouped by ZMYND8-low versus ZMYND8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYND8→partner) and Y-score (partner→ZMYND8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPHN →	+0.303	+1.938	.007	.008	3	4
COAD	PSMB6 →	+0.341	+2.183	.004	.001	3	4
COAD	ERO1A →	+0.573	+2.595	<.001	.006	3	3
UCEC	PRC1 →	+0.422	+1.491	.008	.006	3	3
COAD	LINC01630 →	+0.346	+2.927	<.001	<.001	3	3
COAD	LINC00941 →	+0.897	+2.817	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,481 associations by consensus.

GPHN by ZMYND8 expression — UCEC

Explore this box plot interactively →