ZMYND8

Across TCGA pan-cancer cohorts, ZMYND8 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZMYND8 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZMYND8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZMYND8 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCEC show a favorable association.

UVM, SCLC, and LIHC are the cancer types where ZMYND8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.308	0.828	.001	82	view →
SCLC	OS	Median	III,IV	0.617	0.311	.003	56	view →
LIHC	OS	Tertile	All	0.666	0.860	<.001	56	view →
LGG	OS	Median	All	0.755	0.868	<.001	41	view →
UCEC	OS	Median	IV	0.665	0.286	.004	32	view →
MESO	DFS	Tertile	All	0.246	0.446	.002	30	view →
LUSC	DFS	Quartile	III,IV	0.456	0.835	<.001	25	view →
UCS	DFS	Tertile	IV	0.906	0.275	.024	24	view →
HNSC	DFS	Tertile	IV	0.415	0.215	.010	17	view →
DLBC	DFS	Tertile	All	0.575	1.000	.002	17	view →
BRCA	OS	Tertile	All	0.505	0.689	.001	16	view →
GBM	DFS	Quartile	All	0.474	0.176	.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZMYND8–UVM (DFS)

Open the UVM breakdown →