ZMYND8

Across TCGA pan-cancer cohorts, ZMYND8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZMYND8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZMYND8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZMYND8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, BLCA, and LIHC are the cancer types where ZMYND8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZMYND8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.934	<.001	10	view →
BLCA	All	All	+0.911	<.001	10	view →
LIHC	Female	II,III,IV	+1.260	<.001	8	view →
UCEC	All	All	+0.771	<.001	6	view →
BRCA	All	III,IV	+0.754	<.001	6	view →
STAD	All	II,III,IV	+0.749	<.001	6	view →
KIRP	All	II,III,IV	+0.649	.003	6	view →
HNSC	All	All	+0.523	<.001	6	view →
CHOL	Male	All	+2.380	<.001	5	view →
LUSC	All	All	+0.505	<.001	4	view →
LUAD	All	All	+0.327	.003	3	view →
KICH	Female	All	−0.512	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZMYND8–COAD

Open the COAD breakdown →