ZMYND8

Across TCGA patient cohorts, ZMYND8 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMYND8-associated genes across cancer lineages are JNK2, ATM, and GATA3. Each is linked with ZMYND8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZMYND8-to-partner and partner-to-ZMYND8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ZMYND8-low versus ZMYND8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYND8→partner) and Y-score (partner→ZMYND8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.215	+1.378	<.001	.008	3	3
UCEC	ATM →	-0.544	-1.723	<.001	.005	3	3
BLCA	GATA3 →	+0.822	+3.169	.001	.018	3	2
BLCA	Bak →	+0.254	+2.824	<.001	.034	3	2
COAD	PI3K-p110-a →	-0.099	-1.991	.047	.031	3	2
COAD	PKC-delta_pS664 →	-0.133	-1.991	.013	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

JNK2 by ZMYND8 expression — UCEC

Explore this box plot interactively →