ZMYND8

Across TCGA cell cohorts, ZMYND8 mutation is significantly associated with the RNA expression of many other genes, with 252 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZMYND8-associated genes across cancer lineages are LRRC3B, OR52B2, and TFAP2D. Each is linked with ZMYND8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMYND8-to-partner and partner-to-ZMYND8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3B grouped by ZMYND8-low versus ZMYND8-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMYND8→partner) and Y-score (partner→ZMYND8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRRC3B →	+0.035	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	OR52B2 →	+0.031	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	TFAP2D →	+0.045	+4.643	<.001	.005	3	1
LARGE_INTESTINE	TFIP11 →	+0.349	+2.158	.007	.004	3	1
LARGE_INTESTINE	GCAT →	+1.119	+2.850	.001	<.001	3	1
LARGE_INTESTINE	EIF3L →	+0.543	+3.652	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 252 associations by consensus.

LRRC3B by ZMYND8 expression — BLOOD_Lymphoma

Explore this box plot interactively →