ZIK1

Across TCGA cell cohorts, ZIK1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ZIK1-associated genes across cancer lineages are FEZF2, OR2AK2, and F9. Each is linked with ZIK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIK1-to-partner and partner-to-ZIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEZF2 grouped by ZIK1-low versus ZIK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIK1→partner) and Y-score (partner→ZIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FEZF2 →	+0.010	+2.688	<.001	.008	3	1
OVARY	OR2AK2 →	+0.070	+4.029	<.001	.009	3	1
LUNG_SCLC	F9 →	+0.036	+5.643	<.001	.002	3	1
LUNG_SCLC	FFAR3 →	+0.058	+5.029	<.001	.006	3	1
OVARY	NLRP2B →	+0.070	+4.392	<.001	.004	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FEZF2 by ZIK1 expression — LARGE_INTESTINE

Explore this box plot interactively →