ZIK1

Across TCGA pan-cancer cohorts, ZIK1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZIK1 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZIK1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZIK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, SCLC, and KIRC are the cancer types where ZIK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.663	0.520	<.001	115	view →
SCLC	OS	Median	All	0.506	0.195	<.001	98	view →
KIRC	DFS	Median	All	0.713	0.544	<.001	82	view →
UVM	OS	Tertile	All	0.955	0.542	<.001	58	view →
KIRP	DFS	Tertile	All	0.958	0.820	.001	56	view →
LGG	DFS	Median	All	0.662	0.822	<.001	54	view →
SKCM	DFS	Tertile	II,III,IV	0.602	0.757	.003	33	view →
ESCA	DFS	Median	III,IV	0.449	0.224	.003	31	view →
LUAD	OS	Quartile	III,IV	0.554	0.272	.020	18	view →
GBM	DFS	Quartile	All	0.475	0.189	.004	18	view →
SARC	DFS	Median	All	0.233	0.538	.002	17	view →
ACC	DFS	Tertile	All	0.410	0.685	.012	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZIK1–HNSC (DFS)

Open the HNSC breakdown →