ZIC5

Across TCGA patient cohorts, ZIC5 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,900 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ZIC5-associated proteins across cancer lineages are CDCA8_S219, CEBPZ, and MCM3. Each is linked with ZIC5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZIC5-to-partner and partner-to-ZIC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZIC5 versus CDCA8_S219 in BRCA, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC5→partner) and Y-score (partner→ZIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDCA8_S219 →	+0.841	+0.716	<.001	.003	3	4
LSCC	CEBPZ →	+0.341	+0.682	.003	.002	3	4
PDAC	MCM3 →	+0.388	+0.300	.002	.009	3	4
CCRCC	TOP2A_S1247 →	+0.771	+0.605	.001	.006	3	4
CCRCC	XPOT →	+0.427	+0.429	<.001	<.001	3	4
LSCC	RACGAP1 →	+0.574	+0.788	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,900 associations by consensus.

ZIC5 vs CDCA8_S219 — BRCA

Explore this scatter interactively →