ZIC5

Across TCGA pan-cancer cohorts, ZIC5 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZIC5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZIC5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZIC5 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, LUSC, and COAD are the cancer types where ZIC5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZIC5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.830	<.001	12	view →
LUSC	Male	All	+1.805	<.001	8	view →
COAD	All	II,III,IV	+0.922	<.001	7	view →
LIHC	Female	All	+0.939	<.001	6	view →
BLCA	All	All	+0.879	.001	6	view →
BRCA	Female	II,III,IV	+0.394	<.001	6	view →
LUAD	All	All	+0.350	<.001	6	view →
STAD	Male	II,III,IV	+1.290	<.001	5	view →
UCEC	All	All	+0.819	.009	4	view →
KIRC	All	All	+0.108	.012	4	view →
KIRP	All	III,IV	+0.484	.025	3	view →
PRAD	All	All	+0.892	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZIC5–HNSC

Open the HNSC breakdown →