ZIC5

Across TCGA cell cohorts, ZIC5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZIC5-associated genes across cancer lineages are LIPM, IFNA13, and OR9Q2. Each is linked with ZIC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC5-to-partner and partner-to-ZIC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIPM grouped by ZIC5-low versus ZIC5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC5→partner) and Y-score (partner→ZIC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LIPM →	+0.056	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA13 →	+0.072	+4.930	<.001	.008	3	1
LARGE_INTESTINE	OR9Q2 →	+0.069	+4.977	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
CNS	C10orf71 →	+0.016	+4.981	<.001	.008	3	1
CNS	PRAMEF15 →	+0.352	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

LIPM by ZIC5 expression — SOFT_TISSUE

Explore this box plot interactively →