ZIC4

Across TCGA patient cohorts, ZIC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,691 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ZIC4-associated GO terms across cancer lineages are Protein-containing complex disassembly, Chromosome localization, and mRNA transport. Each is linked with ZIC4 in more than 20 cancer types. Because this analysis shows association rather than direction, both ZIC4-to-partner and partner-to-ZIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-containing complex disassembly grouped by ZIC4-low versus ZIC4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC4→partner) and Y-score (partner→ZIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Protein-containing complex disassembly →	+0.061	+0.154	<.001	<.001	3	21
STAD	Chromosome localization →	+0.069	+0.160	<.001	<.001	3	20
STAD	mRNA transport →	+0.074	+0.145	<.001	<.001	3	20
STAD	Nuclear export →	+0.067	+0.154	<.001	<.001	3	20
STAD	Establishment of RNA localization →	+0.072	+0.151	<.001	<.001	3	20
STAD	Metaphase chromosome alignment →	+0.073	+0.164	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,691 associations by consensus.

Protein-containing complex disassembly by ZIC4 expression — STAD

Explore this box plot interactively →