ZIC4

Across TCGA pan-cancer cohorts, ZIC4 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ZIC4 data layer compared with 11 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZIC4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZIC4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

KIRC, ACC, and MESO are the cancer types where ZIC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.745	0.853	<.001	122	view →
ACC	OS	Median	All	0.409	0.765	<.001	101	view →
MESO	OS	Median	All	0.270	0.492	<.001	94	view →
THYM	DFS	Tertile	All	0.575	0.797	.012	66	view →
HNSC	DFS	Tertile	IV	0.759	0.583	.002	65	view →
KIRP	OS	Median	All	0.468	0.815	<.001	62	view →
UCS	DFS	Median	II,III,IV	0.437	0.157	.021	30	view →
UCEC	DFS	Median	IV	0.878	0.513	.002	24	view →
PAAD	OS	Quartile	II,III,IV	0.808	0.525	.003	20	view →
OV	OS	Tertile	IV	0.545	0.929	.012	16	view →
READ	DFS	Tertile	II,III,IV	0.333	0.693	.024	10	view →
SCLC	DFS	Tertile	II,III,IV	0.274	0.792	.036	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

ZIC4–KIRC (OS)

Open the KIRC breakdown →