ZIC4

Across TCGA pan-cancer cohorts, ZIC4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZIC4’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where ZIC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZIC4 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

UCEC, LIHC, and LUSC are the cancer types where ZIC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZIC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	II,III,IV	+0.980	<.001	6	view →
LIHC	Male	All	+0.662	<.001	6	view →
LUSC	All	All	+0.345	<.001	4	view →
BRCA	Female	All	+0.167	.003	4	view →
LUAD	All	All	+0.200	.001	2	view →
KIRC	Male	All	+0.015	.026	2	view →
BLCA	Male	IV	−0.017	.031	1	view →
COAD	All	All	−0.013	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ZIC4–UCEC

Open the UCEC breakdown →