ZIC4

Across TCGA patient cohorts, ZIC4 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC4-associated genes across cancer lineages are ATM, TIGAR, and ACC1. Each is linked with ZIC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZIC4-to-partner and partner-to-ZIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZIC4-low versus ZIC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC4→partner) and Y-score (partner→ZIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.396	-1.584	.002	.001	3	4
ESCA	TIGAR →	+0.987	+2.999	.001	.031	3	3
LUAD	ACC1 →	+0.262	+1.678	.047	.020	3	2
LUAD	Akt_pS473 →	-0.295	-2.000	.019	.027	3	2
LUAD	p62 Lck ligand →	+0.477	+2.476	.001	.009	3	2
LUAD	PDK1_pS241 →	-0.142	-1.794	.020	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ATM by ZIC4 expression — UCEC

Explore this box plot interactively →