ZIC4

Across TCGA cell cohorts, ZIC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,989 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ZIC4-associated GO terms across cancer lineages are Ventricular cardiac muscle cell action potential, Potassium ion transport, and Positive regulation of double-strand break repair via homologous recombination. Each is linked with ZIC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ZIC4-to-partner and partner-to-ZIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ventricular cardiac muscle cell action potential grouped by ZIC4-low versus ZIC4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC4→partner) and Y-score (partner→ZIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Ventricular cardiac muscle cell action potential →	-0.117	-1.021	.005	.003	3	7
BREAST	Potassium ion transport →	-0.065	-1.117	<.001	.004	3	6
OVARY	Positive regulation of double-strand break repair via homologous recombination →	+0.068	+1.173	<.001	<.001	3	6
SKIN	Transcription initiation at RNA polymerase II promoter →	+0.037	+0.821	.001	<.001	2	7
OVARY	Translational initiation →	+0.063	+1.314	.001	<.001	3	6
SOFT_TISSUE	Host-mediated activation of viral process →	+0.059	+1.188	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,989 associations by consensus.

Ventricular cardiac muscle cell action potential by ZIC4 expression — LUNG_SCLC

Explore this box plot interactively →