ZIC4

Across TCGA cell cohorts, ZIC4 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ZIC4-associated genes across cancer lineages are SCGB3A2, C16orf90, and TAS2R8. Each is linked with ZIC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC4-to-partner and partner-to-ZIC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB3A2 grouped by ZIC4-low versus ZIC4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC4→partner) and Y-score (partner→ZIC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SCGB3A2 →	+0.595	+4.432	.002	<.001	3	2
OESOPHAGUS	C16orf90 →	+0.026	+3.392	<.001	.007	3	2
SKIN	TAS2R8 →	+0.020	+4.467	<.001	.004	3	2
SKIN	BEND2 →	+0.012	+5.022	<.001	.002	3	2
LUNG_NSCLC_LUAD	GH2 →	+0.054	+3.959	<.001	.001	3	2
OESOPHAGUS	SPRR4 →	+1.385	+3.584	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

SCGB3A2 by ZIC4 expression — OESOPHAGUS

Explore this box plot interactively →