ZHX1-C8orf76

Across TCGA patient cohorts, ZHX1-C8orf76 mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZHX1-C8orf76-associated genes across cancer lineages are Fibroblasts, Endothelial cells, and lymphatic Endothelial cells. Each is linked with ZHX1-C8orf76 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZHX1-C8orf76-to-partner and partner-to-ZHX1-C8orf76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblasts grouped by ZHX1-C8orf76-low versus ZHX1-C8orf76-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZHX1-C8orf76→partner) and Y-score (partner→ZHX1-C8orf76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Fibroblasts →	+0.018	+4.475	<.001	.005	3	1
UCEC	Endothelial cells →	-0.039	-3.161	.040	.019	3	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.281	.022	.010	3	1
UCEC	mv Endothelial cells →	-0.026	-3.169	.031	.019	3	1
UCEC	Class-switched memory B-cells →	-0.060	-3.459	.038	.005	2	1
UCEC	MEP →	+0.040	+2.332	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Fibroblasts by ZHX1-C8orf76 expression — SKCM

Explore this box plot interactively →