ZHX1-C8orf76

Across TCGA pan-cancer cohorts, ZHX1-C8orf76 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZHX1-C8orf76 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZHX1-C8orf76 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZHX1-C8orf76 expression acts as an unfavorable survival marker, although some lineages such as THYM and DLBC show a favorable association.

KIRC, UVM, and ACC are the cancer types where ZHX1-C8orf76 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.507	0.733	<.001	192	view →
UVM	DFS	Median	All	0.387	0.775	<.001	146	view →
ACC	DFS	Tertile	All	0.173	0.682	<.001	118	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	93	view →
LIHC	DFS	Quartile	All	0.433	0.648	<.001	79	view →
COAD	DFS	Median	II,III,IV	0.594	0.730	.003	50	view →
LGG	DFS	Median	All	0.773	0.893	<.001	48	view →
UCEC	DFS	Median	All	0.786	0.889	<.001	36	view →
LUAD	DFS	Tertile	All	0.353	0.613	.001	33	view →
ESCA	DFS	Quartile	All	0.238	0.519	.001	30	view →
KICH	DFS	Tertile	III,IV	0.037	0.813	.010	26	view →
PRAD	DFS	Median	All	0.673	0.911	<.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZHX1-C8orf76–KIRC (DFS)

Open the KIRC breakdown →