ZHX1-C8orf76

Across TCGA pan-cancer cohorts, ZHX1-C8orf76 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZHX1-C8orf76’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZHX1-C8orf76 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZHX1-C8orf76 is over-expressed in tumor.

KIRC, BLCA, and COAD are the cancer types where ZHX1-C8orf76 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZHX1-C8orf76 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.399	<.001	12	view →
BLCA	Male	III,IV	+0.948	<.001	11	view →
COAD	Female	II,III,IV	+0.678	<.001	11	view →
HNSC	Male	IV	+0.500	<.001	11	view →
LIHC	Male	II,III,IV	+1.071	<.001	9	view →
UCEC	All	II,III,IV	+1.039	<.001	8	view →
STAD	Female	All	+0.744	<.001	8	view →
LUAD	Male	II,III,IV	+0.664	<.001	7	view →
LUSC	Male	II,III,IV	+0.562	<.001	6	view →
BRCA	Female	II,III,IV	+0.296	<.001	6	view →
READ	All	All	+0.787	<.001	5	view →
KIRP	All	All	+0.194	.039	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZHX1-C8orf76–KIRC

Open the KIRC breakdown →