ZFX-AS1

Across TCGA pan-cancer cohorts, ZFX-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated ZFX-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZFX-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZFX-AS1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and UCEC show a favorable association.

COAD, LUSC, and CHOL are the cancer types where ZFX-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.702	0.853	<.001	66	view →
LUSC	OS	Tertile	IV	0.057	0.786	.008	48	view →
CHOL	OS	Tertile	II,III,IV	1.000	0.342	.006	44	view →
UCEC	DFS	Tertile	IV	0.735	0.233	.008	28	view →
BRCA	OS	Quartile	II,III,IV	0.754	0.559	.009	27	view →
UVM	OS	Median	III,IV	0.318	1.000	.013	25	view →
LIHC	DFS	Quartile	III,IV	0.425	0.184	.012	20	view →
KIRC	DFS	Quartile	II,III,IV	0.419	0.606	.020	17	view →
CESC	DFS	Quartile	All	0.744	0.874	.012	16	view →
KICH	OS	Median	II,III,IV	0.552	0.946	.008	7	view →
READ	DFS	Median	II,III,IV	0.686	0.439	.019	6	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

ZFX-AS1–COAD (OS)

Open the COAD breakdown →