Q-omics provides the consensus-scored ZFX-AS1 profile across patient tissues and cancer cell-line models. ZFX-AS1 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, ZFX-AS1 is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, ZFX-AS1 RNA expression shows 8,897 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight COAD, THCA, and TGCT as cancer lineages where ZFX-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZFX-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZFX-AS1 survival associations across molecular data types. ZFX-AS1 RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZFX-AS1 RNA expression–survival associations across cancer types. High ZFX-AS1 expression shows unfavorable associations in COAD, LUSC and UVM, but favorable associations in CHOL, UCEC and BRCA. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for ZFX-AS1 RNA expression.
This table summarizes ZFX-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ZFX-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZFX-AS1 shows lower tumor expression in THCA and UCEC and higher tumor expression in LUSC, COAD and HNSC. The THCA box plot shows higher ZFX-AS1 RNA expression in normal versus tumor tissue (log2 FC = −0.451, t-test p < 0.001).
This table shows molecular features associated with ZFX-AS1 in patient tissues and cancer cell lines. In patient samples, ZFX-AS1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
