ZFX-AS1

Across TCGA pan-cancer cohorts, ZFX-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ZFX-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZFX-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZFX-AS1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, UCEC, and LUSC are the cancer types where ZFX-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZFX-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.451	<.001	9	view →
UCEC	All	All	−0.268	.029	2	view →
LUSC	All	All	+0.118	.027	2	view →
COAD	All	All	+0.135	.032	1	view →
HNSC	All	All	+0.065	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ZFX-AS1–THCA

Open the THCA breakdown →